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THE PRACTICAL
HOME PHYSICIAN AND ENCYCLOPEDIA OF MEDICINE The biggy of the late 1800's. Clearly shows the massive inroads in medical science and the treatment of disease.
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ALCOHOL AND THE HUMAN BODY In fact alcohol was known to be a poison, and considered quite dangerous. Something modern medicine now agrees with. This was known circa 1907. A very impressive scientific book on the subject. |
DISEASES OF THE SKIN is a massive book on skin diseases from 1914. Don't be feint hearted though, it's loaded with photos that I found disturbing. |
Part of SAVORY'S COMPENDIUM OF DOMESTIC MEDICINE:
19th CENTURY HEALTH MEDICINES AND DRUGS |
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IMPETIGO CONTAGIOSA
Synonyms and Varieties.—Porrigo contagiosa; Impetigo parasitica; Impetigo vulgaris (Unna); Impetigo simplex; Impetigo sparsa; Impetigo streptogenes; Impetigo staphylogenes; Impetigo circinata; Impetigo figurata.
Definition.—Impetigo contagiosa is an acute, contagious, inflam matory disease, characterized by the formation of discrete, superficial, flattened, rounded, or oval vesicles or blebs, often becoming seropurulent, and drying to thin yellowish crusts.
Exceptionally the beginning lesions are small pustules, and which may dry to thicker crusts. And occasional types of a circinate or even serpiginous configuration are noted.
Symptoms.—In a typical case of impetigo contagiosa of the common form of the disease several vesicopapules, vesicles, or ves- icopustules make their appear ance simultaneously or in rapid succession upon the face, face and scalp, or face and fingers, or upon all these various parts. At first small, they tend to in crease in size, becoming de cidedly flattened, with, in some cases, in some of the lesions, a slight relative depression of the central part, as compared to the extending peripheral por tion ; there may even be distinct umbilication. They are super ficial, and, as a rule, are without conspicuous areola and without distinctly inflammatory base. They attain the diameter of a pea or a dime, and when close together, as often noted when about the mouth and chin, coalesce and form one or more large, irregular patches. The contents at first are often purely serous, later becoming milky or seropurulent or even purulent. If a vesicopustule or bleb is broken, a reddish, moist, abraded-looking surface is exposed, secreting a thin watery or puriform liquid, and looking not unlike a superficial burn or abrasion. Several days after the appearance of the lesions they begin to dry to thin, granular, yellow or yellowish, wafer-like crusts, which are but slightly adherent, and later on, when the edges have com menced to loosen, have the appearance of being imperfectly pasted
![](Class_II_Inflammations_Impetigo_Contagiosa-1.jpg) Fig. 99.—Impetigo contagiosa in a girl of ten years, of one week‘s duration, crusting stage already reached; on chin and nose lesions have coalesced.
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on. A not unusual site for a vesicopustule is around a finger-nail, where it is somewhat suggestive of a superficial paronychia. Excoria tions, scratch-marks, or abrasions, if present, soon become, through auto-inoculation, the seat of characteristic lesions. Fresh lesions may appear singly or in crops from day to day, but finally, in the course of several days or a week, new ones cease to form and the malady gradually ends. The crusts soon drop off, leaving behind reddish spots which rapidly fade away. Itching may or may not be present. The whole course of the disease, as a rule, occupies ten days to a few weeks.
Occasionally, in addition to the eruption upon the skin, the conjunc- tival, nasal, or oral mucous membranes may show lesions; and excep tionally the greater part of the eruption may be about and in the nasal orifices and about the lips, and even within the mouth.1 As a rule, there is no constitutional disturbance, but when the eruption is extensive, as it is more apt to be in the epidemic form of the disease, it is preceded by light febrile action and malaise.
![](Class_II_Inflammations_Impetigo_Contagiosa-2.jpg) Fig. 100.—Impetigo contagiosa, with small lesions, in a girl of fourteen years, and of
six days’ duration.
All observers have recognized the existence of anomalous types.2 In some of these the eruption consists of but two, three, or several ill-defined lesions about the nose and mouth, with possibly one or two upon the fingers. In others, again, the eruption is more or less scattered
1 D. W. Montgomery, “The Determination of Impetigo Contagiosa to the Mucous Membranes,” Jour. Cutan. Dis., 1910, p. 445; Cushing, “Stomatitis in Impetigo Contagiosa,” Arch. Pediat., June, 1904 (with literature references); Cornby, La France Medicale, Dec. 24, 1887 (cited by Cushing) records instances of vulvovaginal involve ment.
2 Foster, “Herpes Contagiosus Varioliformis,” Arch. Derm., 1875, p. 97; Corlett, “Impetigo: Its Clinical Forms and Present Status, Including Ecthyma and the so- called Pemphigus Contagiosus,” Cleveland Jour. Med., 1898, vol. iii, p. 513; Allen (general—bullous), Trans. Amer. Derm. Assoc. for 1896; Elliot (general—bullous), Jour. Cutan. Dis., 1894, p. 194; Anthony (various forms), ibid., 1898, p. 218; Stel- wagon (various forms), Phila. Med. Times, Sept. 22, 1883; Engman, “Impetigo Con- tagiosa and Its Bacteriology,” Jour. Cutan. Dis., 1901, p. 180 (with review and bibli ography); Grindon (bullous), ibid., p. 188.
IMPETIGO CONTAGIOSA
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over face, hands, limbs, and to a less extent upon the trunk. In some instances, of more or less general distribution, the lesions, instead of being flat, consist of pea- to nut-sized blebs, flaccid or tense; and when occurring in an epidemic manner among infants and young children the malady simulates, according to the predominant size of the lesions, varicella or pemphigus (impetigo contagiosa bullosa). Most, and proba bly all, of the reported cases of contagious pemphigus and acute pem phigus in infants and children are examples of this variety (impetigo streptogenes?); and exceptionally such cases assume a serious aspect.
In occasional cases they may present segmental or ring-like or ser- piginous configuration (impetigo circinata, impetigo figurata).1 In rare instances, instead of vesicles or blebs, many of the lesions are pustular, and especially those upon the legs, ecthymatous, with a markedly in flammatory base and areola. Exceptionally, as in the variety described by Duhring2 as impetigo simplex (impetigo staphylogenes), the vesicular stage of the disease seems to be wanting, the lesions appearing as pure rounded globular pustules, with little or no tendency to flattening; and
![](Class_II_Inflammations_Impetigo_Contagiosa-3.jpg) Fig. ioi.—Impetigo contagiosa of slight development and showing a circinate patch; of six days’ duration, in a youth of eighteen. Crusting stage already reached.
which, in some cases, may, instead of developing into ordinary matured impetigo lesions, lead to deeper invasion by the organisms and to boil formation. As Bockhart has shown in this type, the lesion is usually follicular. It is seen not infrequently about hairy regions, as the nape of the neck, about the ankles, and other general surface regions in hairy individuals; and in those cases in which the lesions are close together and almost coalescent could be clinically well described as a pyogenic derma titis (dermatitis pyogenica, pyodermia, pyodermatitis, pyodermitis).
It is probable that the rare condition, vacciniform ecthyma of infants,3 is of the nature of impetigo contagiosa; it usually involves the genitocrural
1 See remarkable case by Schamberg, Jour. Cutan. Dis., 1896, p. 169 (with illustra tions).
2 Duhring (a report of 2 typical examples), Amer. Jour. Med. Sci., Oct., 1888; also Leslie Roberts (1 case), Brit. Jour. Derm., 1895, p. 142.
3 Colcott Fox, “Vacciniform Ecthyma of Infants,” Brit. Jour. Derm., 1907, p. 191 (with several illustrations), reports some cases, and reviews the subject, with references; Halle, Dermatolog. Zeitschr., 1908, p. 215 (with colored plate).
400 INFLAMMATIONS
and anal regions. It begins, as a rule, as one, several, or more small papulovesicular elevations on an erythematous base; the vesicular nature is soon manifest, the vesicles becoming larger, flattened, and somewhat superficial, and with central depression, giving the lesions a distinctly vacciniform aspect. Coalescence may occur here and there, resulting in the formation of an irregular surface, or crusted, granulating, eroded, or diphtheroid areas. Sometimes the developed lesions become eroded, and with the slight seropurulent secretion on moist surfaces resemble the eruption of syphilis seen in this region in infants. The intervening skin may be erythematous in its entirety or in spots, the color being of some what dark shade.
In exceptional instances the common sites for impetigo contagiosa may share only slightly in the eruption, or may be entirely exempt, the lesions appearing in unusual regions.1
![](Class_II_Inflammations_Impetigo_Contagiosa-4.jpg) Fig. 102.—Impetigo contagiosa of the ring-like type not infrequently seen in the bearded region of the male adult (courtesy of Dr. H. K. Gaskill).
When seen occurring in adults the eruption consists usually of a few abortive lesions on the face or hands; in some cases, however, it presents numerous discrete and closely crowded pea- to dime-sized or slightly larger lesions about the bearded region and the neck, and which quite frequently show a distinct tendency to ring-like development, the serous and seropurulent formation is often quite scanty, and in such cases the lesions may show considerable resemblance to ringworm patches. This more extensive variety is met with in the male adult and is com monly contracted in barbershops.
1 In 103 cases observed at the Philadelphia Dispensary for Skin Diseases the site was as follows: Face, 49; face and hands, 12; face and limbs, 6; face and scalp, 5; face, scalp, and hands, 5; face, hands, and other parts, 4; face and trunk, 3; face and but tocks, 3; face and feet, 1; legs, 3; trunk and legs, 2; trunk and limbs, 1; hands and neck, 1; hands and buttocks, 1; scalp, 1; buttocks, 1; limbs, 1; distribution more or less general, 4.
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According to Unna,1 the chief differences between the common type observed (his impetigo vulgaris—impetigo contagiosa of T. Fox) and impetigo circinata, impetigo staphylogenes, and impetigo streptogenes are: in impetigo circinata there are no thick crusts, but scales containing more horny cells than serum, and the lesions spread at the borders, form ing discoid and gyrate figures, clearing in the central portions. In impetigo staphylogenes (of Bockhart) the lesions are small pustules with an areola, and are discrete for some time before coalescing, and lead to the formation of comparatively small and thin crusts; the lesions do not remain long as impetigines, but the staphylococcus, by invading the hair- follicles, leads to folliculitis, furuncles, whitlows, etc Im petigo strep togenes lesions commence with serous exuda tion, giving rise to flaccid bullæ, generally large in size, and with grayish-yellow, turbid contents. If the experience of other observers is at all similar to mine, there are instances met with in which the characters of these several types are found in the same case; Sa- bouraud‘s investigations dem onstrate the possible admix ture of two types, primarily to invasion of streptococci, secondarily to staphylococci.
Etiology,—The disease is contagious in all its forms, inoculable and auto-inoculable. From its occasionally occur ring in epidemics it would al most seem as though the malady might in some in stances be infectious. It is observed commonly in the lower ranks of life, although it is not infrequently seen among the wealthier classes. It is largely a disease of infancy and early childhood, being most common between the ages of two and ten; in recent years however a steady increase has been noticeable among older subjects in our preparatory schools and colleges. In men, occurring about the bearded region, it is usually contracted in barbershops. Epidemics have also been noted to occur among youths and adults through interchange of apparel or the use of common or insufficiently cleansed towels, as with football players (football impetigo), in schools, and among bathers (bath-house impetigo) at the shore.
1 Quoting from the abstract of his paper (loc. cit.) in Brit. Jour. Derm., 1899, P- 332. 26
![](Class_II_Inflammations_Impetigo_Contagiosa-5.jpg) Fig. 103.—Impetigo contagiosa in a child of three, and of five days’ duration. Lesions scattered, and more of the nature of the type of “impetigo simplex” described by Duhring.
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INFLAMMATIONS
A relationship to vaccination1 has been noted in some instances, but the same relationship may be said to exist, I believe, to other suppurative processes or lesions. It is also seen in association with pediculosis and scabies; the minute punctures made by the parasites and the excoriations produced by scratching furnishing opportunity for the necessary inocula tion.2
Pathology.—It is known that the disease is due to pus-cocci, staphylococcus aureus, streptococcus and possibly the staphylococcus albus. As intimated in the preliminary remarks, other cocci are doubt-
![](Class_II_Inflammations_Impetigo_Contagiosa-6.jpg) Fig. 104.—Impetigo contagiosa of the male adult, of bearded region and of about a week's duration, showing discrete and confluent lesions; usually contracted in barber shops and presenting lesions more especially on bearded parts of the face and neck, and which are frequently ring-like in character (courtesy of Dr. J. F. Schamberg).
less also etiologic; and it has been alleged by Unna that the various forms have each a specific coccus, but this needs further confirmation. The general belief3 is that it is a staphylococcic affection with a disposi-
1 Stelwagon, “Impetigo Contagiosa: Its Individuality and Nature,” Medical News, Aug. 29, 1883 (out of 88 cases, in 6 only did it follow vaccination; others have, how ever, observed this association in larger proportion. This paper contains most litera ture references to date).
2 See paper by Klotz on “The Infected Scratch and Its Relations to Impetigo and Ecthyma,” Jour. Cutan. Dis., 1896, p. 46.
3 Dr. C. J. White, “The Rôle of the Staphylococcus in Skin Diseases,” Trans. Mass. Med. Soc'y for 1899, gives a good brief review of this question.
IMPETIGO CONTAGIOSA
403
tion to view the other findings as accidental; although French observers for the most part, incline to consider the earliest invasion streptococcic, which is soon concealed or overwhelmed by staphylococci.1 Excep tionally the ringworm or other fungus will provoke somewhat similar lesions (Kaposi, Piffard, Colcott Fox, Geber). Crocker2 was the first to demonstrate clearly that the disease was due to a coccus, and the in vestigations by Unna and Sabouraud, if carefully examined, appear, in fact, to corroborate the correctness of these earlier findings as the cause of some cases of the disease. In some instances—those in which the eruption is epidemic and more or less general in its distribution, and, more especially, the bullous type, with slight constitutional disturbance —the disease certainly bears resemblance to such eruptive fevers as varicella; it is difficult, it is true, to reconcile such examples with the numerous simple cases of undoubted pus-inoculation lesions occurring about the nose, mouth, and hands.
The lesion is formed (Robinson, Unna, Gilchrist, and others) between the rete and horny layer, this latter being the roof-wall; there is a sur rounding mild inflammation. The underlying upper part of the corium displays acute inflammatory action, with the usual features. The lesion contains polynuclear leukocytes in large number, some round mononuclear cells, a few detached epithelial cells, small quantity of fibrin, and a large quantity of coagulated albumin (serum), and, especially in the central portion of the lesion, a large number of the staphylococcus pyogenes aureus, often streptococci, as well as sometimes other cocci.
Diagnosis.—Impetigo contagiosa is to be differentiated from pus tular eczema, ecthyma, varicella, and pemphigus. The patches formed by coalescence bear, it is true, a rough resemblance to pustular eczema; but this latter is accompanied with other symptoms of eczema, such as more or less infiltration and thickening of the involved skin, with intense itching. Moreover, in impetigo contagiosa discrete lesions are always to be found, and these differ from the individual pustules of eczema in greater size, in the absence of a tendency to rupture, and their course.
Impetigo contagiosa differs from ecthyma by the absence of the inflammatory base and areola. The distribution is also unlike the erup tion in the latter malady, being ordinarily upon the face and hands or face and several other parts, while that of ecthyma is commonly seated upon the legs. Moreover, impetigo contagiosa is essentially a disease of childhood, whereas ecthyma is usually observed in adults. In the former, too, the process is superficial and the crusts are thin; in the latter deep-seated, and the crusts are thick.
The lesions of varicella are uniform and smaller, rarely larger than split peas, and more or less disseminated, with no tendency to patch- formation and with insignificant crusting. In those rare cases of im-
1 Dubreuilh and Braudeis, “Note on the Bacteriology of Pyodermatitis,” Annales, June, 1910, p. 323; British Jour. Derm., 1911, p. 91, cannot confirm Sabouraud‘s dictum—“all types beginning with a vesicle or bulla due to streptococci, those beginning with a pustule staphylococcus;" but believe it is sometimes one, sometimes the other, and in some cases mixed.
2 Crocker, Lancet, 1881, vol. i, p. 82.
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INFLAMMATIONS
petigo contagiosa resembling pemphigus the disease must be studied in its entirety, and sometimes for several days before it is possible to be positive as to diagnosis. Pemphigus is exceedingly rare. In true pemphigus the lesions spring from the sound skin usually as blebs of some size from the start, whereas in impetigo contagiosa they are small in the beginning and grow in size by peripheral extension. The eruption of pemphigus has no parts of predilection, and, more over, is generally accompanied by symptoms of constitutional dis turbance. In impetigo contagiosa some of the characteristic lesions are usually present, or frequently another member of the family will present the typical disease.
Prognosis.—The effect of treatment is, as a rule, prompt; indeed, impetigo contagiosa in most instances tends to spontaneous disap pearance in ten days to a few weeks; but in exceptional cases, more especially in those in which itching is present to a sufficient degree to lead to scratching, the excoriations thus made become inoculated, and in this manner the disease, unless actively treated, may persist for one or two months. A pediculosis capitis is also at times a causative factor in prolonged cases.
Treatment.—Treatment consists in the destruction of the auto- inoculable properties of the crusts and contents of the lesions. The crusts should be removed by warm water and soap washing, fresh or distended lesions being first opened. An ointment of 10 to 20 (0.65-1.35) grains of ammoniated mercury to the ounce (32.) of cold cream or petro latum should then be gently but thoroughly rubbed into the secreting base of the lesions two or three times daily. When the crusts are quite adherent and fail to come off with ordinary washing, the salve just named should be applied over the patch, and the washing and such anointing repeated two or three times daily until the crusts come away, after which the ointment should be rubbed into the secreting base. In many of these latter cases, indeed, partial or complete healing will be found to have taken place beneath the crusts. In some instances a drying salve such as Lassar's paste with the addition of the white pre cipitate or 20 to 30 grains (1.33-2.) of sulphur to the ounce (32.) is more satisfactory. Any mildly antiseptic ointment will, however, be found curative.
In markedly itchy cases, in which the disease tends to continue from inoculation of the scratch-marks thus provoked, a lotion of the saturated solution of boric acid, with 5 grains (0.33) of either carbolic acid or resorcin, or both, to the ounce (32.), should, as a preventive measure, be applied two or three times daily to the affected parts gener ally. Ordinarily in all extensive cases this lotion can be advised along with the salve as a routine measure. For lesions occurring on the con junctiva a plain boric acid lotion, 10 grains (0.65) to the ounce (32.), may be dropped in the eye once or twice daily.
In those cases of more or less general distribution, in which mild febrile action is present, in this respect resembling slightly the erup tive fevers, a laxative should be given and the patient kept at com parative rest for a day or two; in other respect, the treatment is the same.
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